The urinary excretion of testosterone and epitestosterone in females following intravenous infusions of testosterone before and during treatment with an antiandrogen (cyproterone).

Abstract

ABSTRACT Intravenous infusions of 10 mg testosterone (T) in two females (one of them adrenalectomized for Cushing's syndrome) resulted in an increased urinary excretion of T-glucuronide, whereas the excretion of epitestosterone (ET)-glucuronide was not altered significantly. The excretion of T-sulphate increased only slightly. During treatment with 100 mg Cyproterone p. d. a marked elevation of urinary T and ET excretion occurred. A slight increase in unconjugated T and ET was also observed. A second T infusion during Cyproterone treatment did not lead to a further increase of urinary T-glucuronide, but there was a slight increase in urinary excretion of ET-glucuronide and of T-sulphate.