Abstract
A simple procedure for the extraction from tissues and determination by gas chromatography of pentazocine was developed. The mean recovery from brain was 96%. The time- and dose-dependent uptake of pentazocine into the brain was investigated and correlated with the plasma levels of the drug. The results showed a rapid entry of pentazocine into the drug. The results showed a rapid entry of pentazocine into at 2 min and 10 min, respectively, after the i.p. administration. After the injection of a single dose, the ratio, concentration of pentazocine in plasma/concentration of pentazocine in brain was constant from 10–90 min. This ratio remained unchanged over the range of 25–100 mg/kg of administered drug.
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