Abstract
ABSTRACT Cellular metabolism in the thyroid gland of patients with Graves' disease, nodular goiter and thyroid cancer was appraised by measuring the incorporation of radiophosphorus (P32). The P32 was administered intravenously twenty-four hours before operation. At the time of surgery, representative specimens were procured from thyroid, muscle and blood. The ratio of counts per minute per milligram of thyroid to counts per minute per .001 milliliter of serum was thought to be the most reliable index of P32 content. Representative “thyroidserum ratios” were as follows: normal thyroid, 23; Graves' disease treated with propylthiouracil and Lugol's solution, 33; Graves' disease treated with propylthiouracil alone, 49; follicular adenoma (nodular goiter), 20; fetal adenoma, (nodular goiter), 40; and carcinoma of the thyroid, 71. Administration of propylthiouracil and Lugol's solution to patients with hyperthyroidism seemed to have little demonstrable effect upon the total incorporation of P32. Neither was P3...
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