Abstract
Recent numerous studies have indicated that uptake and storage of circulating catecholamine by tissues are important in its physiological disposition. At present, however, experimental evidence is not enough to support the view that the uptake of the circulating amine is a rate-limiting factor in synthesis and liberation of the tissue amine and consequently it controls servo-regulation of the amount of circulating amine. King and Marrazzi (1) have suggested that the depressant effect of adrenaline on the pressor response to centrifugal splanchnic nerve stimulation in the eviscerated cat is due to inhibition of transmission through the adrenal glands. Robinson and Watts (2) have shown that the secretion of adrenaline from the adrenal glands markedly decreased during the infusion of catecholamine. However, they did not discuss the decrease of the liberation or the secretion in relation to the uptake of amine by the tissues. In the present experiments the content of noradrenaline or adrenaline in tissues such as brain, heart, spleen and adrenal glands of the unanesthetized but restrained rabbits in response to continuous infusion of noradrenaline was determined chemically.
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