Abstract
Francisella tularensis is a highly infectious Gram-negative bacterium causing the zoonotic disease tularemia. This facultative intracellular pathogen multiplies in vivo mainly inside macrophages, but has the capacity to infect and survive in many other cell types, including other phagocytic and nonphagocytic cells. In vitro, F. tularensis escapes rapidly from the phagosomal compartment and replicates in the cytoplasm of infected cells. An impressive number of novel genes related to F. tularensis pathogenesis have been identified recently. However, the information on biological functions still remains limited to a few of them. In this review, we will try to provide a comprehensive overview of the bacterial attributes, currently known-or suspected-to participate in F. tularensis virulence and will highlight the future challenges in F. tularensis research.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.