Abstract
The Unfolded Protein Response Is Required for Haploid Tolerance in YeastJournal of Biological ChemistryVol. 278Issue 14PreviewHAC1 encodes a transcription factor that mediates the unfolded protein response (UPR) inSaccharomyces cerevisiae. We characterizedhac1Δ mutants in the sporulation-proficient SK1 genetic background and found a novel function for HAC1 in haploid tolerance. hac1Δ spore clones contain a diploid DNA content as determined by fluorescence-activated cell sorting and genetic analyses. Autodiploidization of hac1 spore clones occurred after germination; hac1 spores were born haploid, but efficiently generated diploid progeny during the subsequent mitotic division. Full-Text PDF Open Access Vol. 278 (2003) 11818-11827 Page 11818: The symbol for Dr. Neigeborn's affiliation was incorrect. The corrected author list with affiliations is shown below: Kyungho Lee‡§, Lenore Neigeborn¶, and Randal J. Kaufman‡∥ From the ‡Howard Hughes Medical Institute, Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan 48109 and ¶Rutgers College, New Brunswick, New Jersey 08901
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