Abstract

Endothelial progenitor cells (EPCs) derived from bone marrow,play crucial roles in the maintenance of endothelial cell integrity and in the neovascularization of ischemic tissue.The mechanisms of EPCs impairment in diabetes include increased production of reactive oxygen species,reduced bioavailability of endothelial nitric oxide synthase,activated process of inflammation and inhibited signaling pathways of angiogenesis related proteins.These multiple abnormalities contribute to defective angiogenesis,resulting in cardiovascular complications,delayed wound healing and ascending risk of lower limb amputation in diabetes.By exploring new targets acting on dysfunction of diabetic EPCs,new approaches to prevent and cure cardiovascular events and foot disorders could be found through improving EPCs function in patients with diabetes. Key words: Diabetes mellitus ; Endothelial progenitor cells; Angiogenesis

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