Abstract
In the present study an attempt to detect influence of some psychotropic drugs on oxidative phosphorylation has been made. Relanium and melipramine were used in the experiments. They are among tranquilizer and antidepressant drug groups respectively. It was shown that both drugs increased the rate of oxygen consumption and displayed uncoupling properties. Mitochondrial respiration raised up slowly after drug addition in the presence of succinate or beta-oxybutyrate as oxidized substrates. If concentration of relanium and melipramine exceeded 1.2 and 0.8 mM respectively the rate of oxygen consumption began to decrease. There was a small reply on addition of ADP in the presence of drugs. At the same time relanium and melipramine decreased respiration rate if they were added at the state 3. It was shown that the drugs increased conductivity of bimolecular phospholipid membranes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
