Abstract
The parafollicular cells of the rat thyroid gland have been studied in the light and electron microscope on a material fixed by perfusion with glutaraldehyde followed by immersion in osmic acid. By studying alternating light and electron microscopical sections it was established that, with the preparation technique used here, the follicle cells and parafollicular cells can be differentiated with great safety in the light microscope. In the electron microscope the parafollicular cells are characterized by an abundance of dense granules; a very extensive Golgi apparatus; an endoplasmic reticulum consisting of narrow, orderly arranged cisternae; slender mitochondria with obliquely and longitudinally arranged inner membranes; and an evenly outlined cell nucleus. The specific granules seem to develop in the Golgi region, where all transitions from Golgi saccules to granules of mature appearance are seen. In an intermediate stage of the development the granules are furnished with a bristle-coated bounding membrane.
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