Abstract
The ultrastructure of the cells of normal germinal epithelium of healthy dogs is described and compared with that of tumour cells of 16 canine seminomas. Both normal and tumour cells are characterized by oval nuclei, straight cell borders, relative scarcity of cytoplasmic organelles, and distinct Golgi complex. Intercellular bridges, as seen in normal germinal cells, are not present in seminomas, desmosomes occur in tumour cells only. Two types of tumour cells are described, distinguishable from each other by shape, cytoplasmic density and content of organelles. They are considered to be stages of differentiation of one particular tumour cell. In all cases the cells are markedly distinct from cells of Leydig cell tumours and Sertoli cell tumours.
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