Abstract
The Ugi reaction with CF 3-carbonyl compounds is described in detail. The method is efficient for the multicomponent preparation of α-trifluoromethyl (Tfm) amino acids, α-Tfm containing dipeptides, and iminodicarboxylic acids. In addition, the first protected CF 3-opine derivative was prepared. The scope, limitations, and stereochemistry of the approach are discussed.
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