Abstract
The p50 subunit of nuclear factor-kappa B (NF-κB) is generated from processing of the p105 precursor. We identified KIP1 ubiquitination-promoting complex 1 (KPC1) as the ubiquitin (Ub) ligase mediating this process. Overexpression of KPC1 results in tumor suppression, probably due to the generation of p50–p50 homodimers. It appears that high levels of KPC1 and nuclear p50 are important for maintaining the non-malignant state.
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