Abstract
There were determined free plasma tyrosine and tryptophan spectral-photofluorometrically at 22 healthy controls and 81 depressed patients (13 of them were controlled in a long-time-study; mean time: 11 months, and 68 patients were controlled ambulant). The biochemical data were demonstrated in a tyrosine-tryptophan diagram and were correlated with the clinical behaviour of the patients. This correlation only was possible with the postulation of a balance between catecholamine-and indolamine metabolism. Three biochemical parameters are necessary. The values of 1. tyrosine that of 2. tryptophan and not only 3. the resulting quotient. With help of such demonstration we showed this tyrosine-tryptophan balance graphically. We think, that both catecholamine-and the indolamine-hypothesis of depression seem to have their availability.
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