The tudy of the cerebral circulation in Scandinavia.

Abstract

Proceedings of the British Institute of RadiologyPublished Online:29 May 2014https://doi.org/10.1259/0007-1285-42-500-637SectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail AboutAbstractThere are a number of indicator dilution or indicator fractionation techniques which are applicable to the measurement of cerebral blood flow (CBF). These methods and their underlying principles have been reviewed briefly elsewhere (Veall, 1968). A number of important techniques exist which are not covered in detail in the present Symposium; of particular importance is the Kety-Schmidt method (1948), partly for historical reasons and partly because it is the method which has to be employed for cerebral metabolic studies. The same workers were the first to adopt the indicator fractionation technique to demonstrate the variation in blood flow between different regions and structure of the brain in cats (Landau, Freygang, Roland, Sokoloff and Kety, 1955). This technique is not applicable clinically since it involves decapitation of the animal. However, Sapirstein (1962) has attempted to apply the same principle using 42K and 131I antipyrine as indicators and external counter uptake measurements for CBF studies in man, albeit with limited success. More recently, the indicator fractionation technique is becoming increasingly widely employed using labelled albumin macroaggregates and scanning techniques for the delineation of infarcted areas and for the quantitation of intracerebral shunts (Nagai, Jimbo and Sano, 1967); earlier misgivings about the safety of the procedure seem to have been largely dispelled by the work of Kennady, Taplin, Griswold and Yamaguchi (1966). Previous article Next article FiguresReferencesRelatedDetails Volume 42, Issue 500August 1969Pages: 561-640 © The British Institute of Radiology History Published onlineMay 29,2014 Metrics Download PDF