The TT genotype of the rs6860 polymorphism of the charged multivesicular body protein 1A gene is associated with susceptibility to fibromyalgia in southern Spanish women.

Abstract

In 2012, Barbosa et al. analysed the association between the genotype frequencies of the rs4680 and rs4818 polymorphisms of the catechol-O-methyltransferase (COMT) gene. Of note is that, in the abstract, they mentioned the rs6860 polymorphism when it should have been rs4680. Indeed, the rs6860 polymorphism is not part of the COMT gene. The rs4680 and rs4818 polymorphisms are related to the COMT gene, which is the most widely studied gene in fibromyalgia. In the present study, we measured the rs4680 and rs4818 polymorphisms of the COMT gene and the rs6860 polymorphism of the CHMP1A gene in 313 women with fibromyalgia and 111 healthy women (control group). We observed similar frequencies of the rs4680 and rs4818 polymorphisms genotype, while the TT genotype and the T allele of the rs6860 polymorphism were more frequent in the case group compared to the control group. Additionally, the level of pain in the past 7 days was assessed with the revised fibromyalgia impact questionnaire. One-way analysis of variance indicated that, in fibromyalgia, pain was similar for all the genotypes of the rs4680, rs4818, and rs6860 polymorphisms (p = 0.41, 0.47, and 0.60, respectively). In the present study, the association of the rs4680 and rs4818 polymorphisms of the COMT gene with fibromyalgia, either susceptibility or pain, previously observed by Barbosa et al. in Brazil, did not emerge among Spanish women. Thus, our findings agree with a recent meta-analysis concluding that these polymorphisms are not associated with having fibromyalgia. The TT genotype of the rs6860 polymorphism of the charged multivesicular body protein 1A gene is associated with susceptibility to fibromyalgia in southern Spanish women (PDF Download Available). Available from: https://www.researchgate.net/publication/321832317_The_TT_genotype_of_the_rs6860_polymorphism_of_the_charged_multivesicular_body_protein_1A_gene_is_associated_with_susceptibility_to_fibromyalgia_in_southern_Spanish_women [accessed Jan 31 2018].