Abstract
BackgroundRecently, some studies claim that adipokines may modulate plasma lipids. More interestingly, the ADRB3 Trp64Arg polymorphism may regulate adipokines and play an essential role in lipids metabolism. This study aims to clarify the associations of ADRB3 Trp64Arg polymorphism with plasma adipokines and lipid levels.MethodsTwenty-two studies (5527 subjects) and 121 studies (54,059 subjects) were respectively identified for the association analyses of adipokines and lipids. Standardized mean difference (SMD) and 95% confidence interval (CI) were used to estimate the strength of the Trp64Arg variant in adipokines and plasma lipids. All results were recalculated after eliminating the studies with heterogeneity.ResultsThe carriers of the C allele (Arg at 64th position was encoded by the C allele) had higher levels of leptin and lower levels of adiponectin than the non-carriers. The carriers of the C allele had higher levels of triglycerides (TG), total cholesterol (TC), and lower levels of high-density lipoprotein cholesterol (HDL-C) than the non-carriers. Subgroup analysis certified an ethnicity (Asians), disease status (obesity), and gender (females) specific association. Sensitivity analysis indicated that the analysis results were robust and stable. Meta-regression indicated that obesity was related to adiponectin.ConclusionsThe C allele carriers of Trp64Arg polymorphism had a slight but significant influence on lipid levels, and the remarkable effects specific existed in obese Asian women. The associations of Trp64Arg polymorphism with dyslipidemia may partly be mediated by the effect of this polymorphism on adipokines. The association of Trp64Arg polymorphism with obesity may partly be mediated by the effect of this polymorphism on adipokines. The C allele carriers had abnormal levels of adipokines and lipids, and it indicated that the Trp64Arg polymorphism might represent a genetic risk factor for coronary artery disease (CAD).
Highlights
coronary artery disease (CAD) obtains the highest mortality and disability rate in most of the developed and developing countries
The present study showed that the β3 adrenergic receptor (ADRB3) Trp64Arg polymorphism is robustly associated with abnormal levels of adipokines and lipids
The C allele carriers of Trp64Arg polymorphism had a slight but significant influence on lipid levels, and the remarkable effects specific existed in obese Asian women
Summary
CAD obtains the highest mortality and disability rate in most of the developed and developing countries. CAD is triggered by multiple genetic and environmental risk factors Among these risk factors, the abnormal levels of adipokines [1, 2] and lipids [3] are widely reported about their essential roles in the occurrence and progress of CAD. The abnormal levels of adipokines [1, 2] and lipids [3] are widely reported about their essential roles in the occurrence and progress of CAD Both leptin and adiponectin are called adipokines, produced by white adipose tissue, one of the most potent lipid regulator [4,5,6], and plays a vital role in lipid metabolism [7,8,9]. This study aims to clarify the associations of ADRB3 Trp64Arg polymorphism with plasma adipokines and lipid levels
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