Abstract
A new class of regulatory small non-coding RNAs called tRNA-derived fragments (tRDFs) has distinct biological roles in various types of cancer. In this issue of Molecular Therapy – Oncolytics, Zitong Gao et al. performed a thorough study of tRDFs in 1,550 patient samples of non-small cell lung cancer (NSCLC) and discovered 52 tRDFs with four subtypes. Based on expression profiles, six tRDFs were selected as diagnostic biomarkers. Two of these biomarkers were successfully validated in plasma samples, and six biomarkers confirmed the consistency of distinguished expression in NSCLC cell lines.
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