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Abstract
The triphenylmethyl (trityl) group can be removed from 5′-trityl 2′-deoxynucleosides (and their N-acyl derivatives) under aprotic neutral conditions without causing any side reactions. An efficient method for tritylation of N-acyl 2′-deoxynucleosides is described. Potential use of such derivatives for stepwise synthesis of deoxyoligonucleotides is discussed.
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