Abstract
AbstractCOVER PHOTOGRAPH: Signaling by the Wingless morphogen (a member of the Wnt family of secreted glycoproteins) is required for the proper development of appendages in Drosophila. Overexpression of Axin, a negative regulator of Wnt signaling, leads to severe defects in Drosophila wing growth and patterning (the affected wing is shown in a green pseudocolor, compared to a wild‐type wing in pink). The inhibitory activity of Axin can be suppressed by co‐expression of the GTP‐binding protein Gαo, leading to a partial rescue in wing development (yellow). Gαo physically binds the RGS domain of Axin and recruits Axin it to the plasma membrane, antagonizing the Axin‐based destruction complex. From Egger‐Adam and Katanaev, Developmental Dynamics 239:168–183, 2010. © 2009 Wiley‐Liss, Inc.
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