Abstract
Objective: The triglyceride-glucose (TyG) index is known to be a simple surrogate marker of insulin resistance. The aim of this study was to investigate association between the TyG index and the two- dimensional longitudinal left vetricular global strain in treated hypertensive patients. Design and method: A total of 75 treated hypertensive patients were enrolled in this study. Anthropometric and cardiovascular risk factors were measured. The TyG index was calculated as ln[fasting triglycerides (mg/dl) × fasting glucose(mg/dl)/2]. The two- dimensional longitudinal left vetricular global strain where evaluated and express in absolute value. Others echocardiographic parameters where mesured: E/E’, left atrial volume and biological parameters: Total cholesterol, HDL cholesterol, LDL cholesterol and glomerular filtartion. Multivariable linear regression analysis was performed to identify the associations between this parameters. Results: Multivariable linear regression analysis showed that a higher TyG index was associated with lower global longitudinal LV strain (p = 0,04), higher body mass index (p = 0,000), higher E/E’ (p = 0,009) and lowest glomerular filtration rate (p = 0,001). Conclusions: A high TyG index was significantly associated with a low global longitudinal LV strain. The results suggest that the TyG index, as a simple indicator of insulin resistance, may reflect subclinical cardiac dysfunction.
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