Abstract
The Tricky Balancing Act of using Heat Shock Proteins for Cross-Presentation
Highlights
On the other hand, binding of Heat shock proteins (HSPs) to another dendritic cells (DC)-expressed scavenger receptor, SRA/CD204 inhibits immune
Murshid et al. (2012) provide an excellent overview of current knowledge on the pathways contributing to cross-presentation of HSP-associated antigens by MHC class I molecules, and on potential mechanisms supporting the induction of robust CD8 T cell responses to HSP-delivered antigens
The authors identify different scavenger receptors that are expressed on dendritic cells (DC) and have been shown to bind extracellular HSPs, leading to antigen cross-presentation
Summary
On the other hand binding of HSPs to another DC-expressed scavenger receptor, SRA/CD204 inhibits immune. HSPs can activate both the innate and adaptive immune system, with the latter function attributed to their ability to shuttle antigens into both the MHC class I and class II antigen processing pathways.
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