Abstract

Only very few studies have investigated the influence of eosinophils in the functional progression of COPD. We aimed to retrospectively analyse the trend of pulmonary function tests over time in patients with COPD according to two baseline blood eosinophil (EOS) cell count strata ( 2 ) higher (p=0.37) than in EOS ≥2% group. Changes from baseline (0-4 yrs) and slope in our EOS The integrated evaluation of our results suggests that the different level of blood EOS in the two groups may have influenced independently the time course of the pulmonary function tests, and can identify two subgroups of subjects with specific disease characteristics: the emphysema-hyperinflated and the rapid decliner, respectively.

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