Abstract
Polycystic ovary syndrome (PCOS) is a frequent gynecological female endocrinopathy, characterized by chronic anovulation, hyperandrogenism, and insulin resistance (IR). Menstrual disorders are one of the main clinical manifestations of PCOS. Other symptoms include hirsutism and/acne. At present, the treatment of PCOS with irregular menstruation is mainly based on oral contraceptives, but there are some side effects and adverse reactions. In recent years, more and more attention has been paid to the complementary and alternative medicine (CAM), which has been widely used in clinical practice. Modern Western medicine is called “conventional medicine” or “orthodox medicine,” and the complementary and alternative medicine is called “unconventional medicine” or “unorthodox medicine.” CAM includes traditional medicine and folk therapy around the world. Around 65–80% of world health management business is classified into traditional medicine by the World Health Organization, which is used as alternative medicine in Western countries. In our country, Chinese medicine, acupuncture, and other therapies are commonly used due to their significant efficacy and higher safety. Therefore, this review aims to summarize and evaluate the mechanisms and the effect of current complementary replacement therapy in the treatment of menstrual disorders caused by PCOS, so as to provide guidance for the following basic and clinical research.
Highlights
Polycystic ovary syndrome (PCOS) is a common gynecologic endocrine disease, characterized by high androgen, persistent anovulation, and polycystic ovary changes. e prevalence of PCOS in women of childbearing age ranges from 6% to 21% [1],; the cause of this disease is still unclear [2, 3]
An article written by Rostami et al [5] summarized and proposed that women have irregular menstruation due to the dysfunction of the ovario-thyroid axis. e menstrual disorder caused by PCOS are mainly caused by the complex endocrine characteristics of PCOS, high blood androgen level, elevated luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio, and excessive insulin, which will affect ovulation of the ovary and lead to menstrual disorders
We find that the experiment conducted by Zhang [37] studied the pharmacologic effects of Diane-35, probiotics, and BBR on PCOS patients from the perspective of intestinal microflora. e authors had consulted other experiments showing that BBR could improve insulin resistance (IR) of PCOS patients during the experiment
Summary
PCOS is a common gynecologic endocrine disease, characterized by high androgen, persistent anovulation, and polycystic ovary changes. e prevalence of PCOS in women of childbearing age ranges from 6% to 21% [1],; the cause of this disease is still unclear [2, 3]. Speaking, BBR can significantly improve PCOS menstrual disorder [34]; it is effective in improving IR in PCOS patients and regulating menstrual cycle by improving metabolism. Compared with other groups, such as IR -β and IRS-1 tyrosine phosphorylation level and IRS-1/PI-3 kinase combined with oral cinnamon group, the results showed that cinnamon extraction can improve the effect of insulin by increasing glucose uptake in vivo. It can be concluded that cinnamomum cassia can improve IR and regulate the metabolic level of the body, so as to improve the menstrual disorder of PCOS patients. After testing the levels of T and serum insulin, the results showed that cinnamomum cassia could restore the cell cycle and ovarian morphology of PCOS mice induced by DHEA. In this paper, [44] speculated that the occurrence of adverse reactions may be related to variable dose
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