Abstract

The high level of sexually transmitted infections (STIs) in South Africa can be attributed to a large number of factors including low socio-economic conditions, social stigma, gender inequalities, inability to access adequate health care systems and lack of preventative programmes. The main curable STIs consist of chlamydia, gonorrhoea, syphilis and trichomoniasis, most of which occur in the developing world. The inability to adequately treat the infections leads to morbidity and has wide-ranging consequences on reproductive health and the health of infants. Due to the inefficient treatment of STIs, the World Health Organisation (WHO) recommended and promoted the syndromic management of STIs in developing countries at the point of contact with the health service provider with the intention of improving the quality of care of these patients. The syndromic approach to STI management depends on patient symptoms and the signs presented at the clinical examination. The four main syndrome management protocols are for urethral discharge and swollen testes, genital ulcers, vaginal discharge and lower abdominal pain in women. After identification of a syndrome, combined therapy is utilised to treat the common causes of the infection. A diagnosis can be made quite rapidly without the need for expensive equipment and tests or special skills. Health care providers make use of flow charts or algorithms for diagnosis and treatment. Algorithms or flowcharts should be adapted to local conditions taking into consideration aetiology, local antimicrobial susceptibility patterns and drug availability. These protocols will help with the prevention and treatment STIs in South Africa.

Highlights

  • Transmitted infections are infections caused by bacteria, viruses and parasites that are transferred mainly via sexual contact, be it vaginal, anal, oral or in some instances via non-sexual means, i.e. by means of blood or blood products

  • Mother-to-child transmission of e.g. chlamydia, gonorrhoea, syphilis, hepatitis B and HIV can occur during pregnancy and childbirth.[1]

  • There are various tests that can be utilized for diagnosis, e.g. culture, enzyme-linked immunosorbent assays (ELISAs), direct immunofluorescence assays (DFAs) and nucleic acid amplification tests (NAATs)

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Summary

Most common bacterial STIs and their treatment

Chlamydial infections are the most common STIs, occurring predominantly in young sexually active adults. A chlamydia infection does not display any symptoms in many patients, pain during urination as well as a discharge or vaginal bleeding has been noted.[3] There are various tests that can be utilized for diagnosis, e.g. culture, enzyme-linked immunosorbent assays (ELISAs), direct immunofluorescence assays (DFAs) and nucleic acid amplification tests (NAATs). Neonatal conjunctivitis in infants, which may result in blindness, is transferred from mothers that have the infection This infection can be diagnosed clinically by vaginal and urethral discharge or in countries with laboratory support by using culturing or nucleic acid amplification tests (NAATs).[4] Due to the rapid changing antimicrobial susceptibility patterns for gonorrhoea, treatment is challenging and may eventually lead to untreatable infections. For further details on dosages and retreatment, refer to the WHO treatment guidelines.[17]

Syndromic treatment of STIs
Local factors responsible for revision in syndromic flowcharts
Genital ulcer aetiology changes
HIV testing
Syndromic treatment flowcharts
Neonatal Conjunctivitis
Conclusion
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