THE TREATMENT OF ROCKY MOUNTAIN SPOTTED FEVER WITH CHLOROMYCETIN

Abstract

Article1 October 1948THE TREATMENT OF ROCKY MOUNTAIN SPOTTED FEVER WITH CHLOROMYCETINMAURICE C. PINCOFFS, M.D., F.A.C.P., ERNEST G. GUY, M.D., LEONARD M. LISTER, THEODORE E. WOODWARD, M.D., JOSEPH E. SMADEL, M.D.MAURICE C. PINCOFFS, M.D., F.A.C.P.Search for more papers by this author, ERNEST G. GUY, M.D.Search for more papers by this author, LEONARD M. LISTERSearch for more papers by this author, THEODORE E. WOODWARD, M.D.Search for more papers by this author, JOSEPH E. SMADEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-4-656 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe demonstrated efficacy of Chloromycetin in the treatment of human cases of scrub typhus1encouraged belief that this new antibiotic might likewise prove effective in the therapy of Rocky Mountain Spotted Fever. During the months of May, June, and July, 1948, a total of 17 cases with the clinical diagnosis of Rocky Mountain Spotted Fever were treated with Chloromycetin.†In 16 of these cases adequate confirmation of the clinical diagnosis was obtained through animal inoculation and serological tests. One of these cases was discarded because of the stage of the disease. The present report deals with the therapeutic results obtained...Bibliography1. SMADELWOODWARDLEYPHILIPTRAUBLEWTHWAITESAVOOR JETEHLCBRRSR: Chloromycetin in the treatment of scrub-typhus (read before the International Congress for Tropical Disease, Washington, D. C., May 11, 1948). Science (in press). Google Scholar2. EHRLICHBARTZSMITHJOSLYNBURKHOLDER JQRRMDAPR: Chloromycetin, a new antibiotic from a soil actinomycete, Science, 1947, cvi, 417. CrossrefGoogle Scholar3. SMITHJOSLYNGRUHZITMCLEANPENNEREHRLICH RMDAOMWIMAJ: Chloromycetin: biological studies, Jr. Bact., 1948, lv, 425. CrossrefGoogle Scholar4. SMADELJACKSON JEEB: Chloromycetin, an antibiotic with chemotherapeutic activity in experimental rickettsial and viral infections, Science, 1947, cvi, 418. CrossrefGoogle Scholar5. SMADELLEONLEYVARELA JEHEHLG: Chloromycetin in the treatment of patients with typhus fever, Proc. Soc. Exper. Biol. and Med. (in press). Google Scholar6. PAYNEKNAUDTPALACIOS EHJAS: Treatment of epidemic typhus with Chloromycetin, Jr. Trop. Med. and Hyg., 1948, li, 68. Google Scholar7. WOODWARDSMADELLEYGREENMANKIKAR TEJEHLRDS: Preliminary report on the beneficial effect of Chloromycetin in the treatment of typhoid fever, Ann. Int. Med., 1948, xxix, 131. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 1, 1948.From the Department of Medicine, University of Maryland School of Medicine and The Department of Virus and Rickettsial Diseases, Army Medical Department Research and Graduate School.†The Chloromycetin used in this work was furnished by the Research Division of Parke Davis and Company.‡Dr. Paul R. Burkholder, Osborn Botanical Laboratory, Yale University. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCHEMOTHERAPY: THE LABORATORY ASSESSMENT OF NEW DRUGSRickettsia rickettsii (Rocky Mountain Spotted Fever)Rocky Mountain Spotted FeverRocky mountain spotted feverBacillary Angiomatosis in a Patient with AIDSAntimicrobial therapy of rickettsial diseasesRocky Mountain Spotted Fever in the ElderlyThe Clinical Use of ChloramphenicolRocky Mountain Spotted Fever in the Eastern United StatesRocky mountain spotted fever in childrenGENERAL PHARMACOLOGY OF ANTIBIOTICSTHE TREATMENT OF RICKETTSIALPOX WITH ANTIBIOTICSCortisone as an Adjunct to Chloramphenicol in the Treatment of Rocky Mountain Spotted FeverNodal tachycardia in a case of rocky mountain spotted feverThe Cause of Simple GoitreChloramphenicol in Penicillin-resistant InfectionKlinik der RickettsiosenKlinik der RickettsiosenRocky Mountain Spotted FeverFurther experience in the treatment of rocky mountain spotted fever with chloramphenicolUse of chloromycetin in infectionsDermatologic TherapyRocky mountain spotted fever treated with chloramphenicol and aureomycinAureomycin Treatment of Herpes ZosterChloramphenicol (chloromycetin) in the treatment of infectious diseasesChloromycetin in the Successful Treatment Of Recurring Epididymitis 1Rocky mountain spotted fever treated withchloromycetinAureomycin in typhus and brucellosisChloromycetin 1 October 1948Volume 29, Issue 4Page: 656-663KeywordsAntibioticsGraduate medical educationHyperthermiaInoculationResearch laboratoriesRocky Mountain spotted fever ePublished: 1 December 2008 Issue Published: 1 October 1948 PDF downloadLoading ...