The treatment of Methicillin-resistant Staphylococcus aureus corneal ulcer after ocular trauma

Abstract

Objective To investigate the treatment of traumatic Methicillin-resistant Staphylococcus aureus (MRSA) corneal ulcer after ocular trauma. Methods The data of 5 eyes of 5 patients with MRSA corneal ulcer after injury from Jan.2014 to Dec.2015 were collected and analyed retrospectively. The infection was determined by taking the eye discharge for bacterial culture and drug sensitivity test. All cases were treated with two kinds of antibiotic eyedrops for many times after sampling. MRSA was cultured in 5 specimens, the drug sensitivity test showed that all of them were sensitive to Vancomycin. Four cases were treated with 50mg/mL Vancomycin eye drops. Penetrating keratoplasty was performed in 1 patient with corneal perforation. After operation, 50mg/mL vancomycin eye drops was used to control the infection. Results The symptom of 4 patients were relieved within 24-48 hours. Corneal epithelial rehabilitation on the surface of the ulcer occurred within 10-14 days. After 1 month follow-up, the corneal ulcer healed completely. No recurrence happened in 1 patient with corneal perforation, after the combination treatment of penetrating keratoplasty and vancomycin eye drops for 2 weeks.Three months after surgery, the uncorrected visual acuity was 0.4. During the period of hospitalization, there was no hospital-acquired MRSA case. Conclusion For MRSA corneal ulcer after ocular trauma, the application of sensitive antimicrobial and multi frequency drops can control the disease development effectively. Key words: Staphylococcus aureus, Methicillin-resistant; Corneal ulcer