Abstract
The treatment of metastatic prostate carcinoma with BNCT in the ITU TRIGA MARKII reactor on rat model
Highlights
Boron neutron capture therapy (BNCT) is a two-stage treatment modality, which stays on the basis of selective accumulation of non-radioactive boron-10 (10B) into the tumor cells via boron carriers and irradiation of 10B loaded tumor cells with low-energy, thermal and epithermal neutrons (≤10 keV) (≈109 n sec/cm2)
We investigated the efficiency of BNCT application by using our novel 10B carrier that was called as 10B-DG on prostate cancer (PCa) using an in vivo mouse xenograft model
Positron Emition Tomography (PET)-CT scan results revealed that 18FDG uptake was stopped in the BNCT treated group due to metabolic inactivation of ablated tumor tisue
Summary
Boron neutron capture therapy (BNCT) is a two-stage treatment modality, which stays on the basis of selective accumulation of non-radioactive boron-10 (10B) into the tumor cells via boron carriers and irradiation of 10B loaded tumor cells with low-energy, thermal and epithermal neutrons (≤10 keV) (≈109 n sec/cm). Boron neutron capture therapy (BNCT) is a two-stage treatment modality, which stays on the basis of selective accumulation of non-radioactive boron-10 (10B) into the tumor cells via boron carriers and irradiation of 10B loaded tumor cells with low-energy, thermal and epithermal neutrons (≤10 keV) (≈109 n sec/cm2) The capturing of these neutrons by 10B causes the nuclear fission reactions, which result in the release of high toxic alpha particles (4He) and 7Li nuclei [1,2,3,4]. The developement of new delivery agents with more effectivity and tumor cell sensitivity is required to improve the deficiencies of current agents
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