Abstract

In a double blind controlled study 41 children with infectious asthma received 0.15 ml.per pound of body weight of pooled gamma globulin at 2 weekly intervals for a total of 8 injections. Twenty-nine children in a concurrent control group received 8 intramuscular injections of a placebo, human serum albumin, identical in appearance to gamma globulin. No reduction in the incidence of asthmatic attacks was observed in the treated as compared to the control group. No evidence was obtained that pooled gamma globulin prepared from the adult blood donors supplied antibodies effective in preventing upper respiratory infections in children. None of the children developed antibodies to components of pooled gamma globulin.

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