Abstract
Abstract This study was undertaken in the search for an agent to dissipate the cardiac effects of digoxin by lowering its concentration in the serum. Digoxin, 0.1 mg. per kilogram, was administered intravenously to two groups of dogs. After two hours, electrocardiograms were recorded and one animal group was treated with penicillamine in the dosage of 1 Gm. per kilogram, given intravenously. This treatment was omitted in the control animals. Two hours after the treatment, venous blood samples were collected and the electrocardiographic recordings were repeated. The average serum digoxin levels in the treated group was 2.60 ± 0.29 ng. per milliliter as compared to 3.73 ± 0.30 ng. per milliliter in the control group. Thus, the serum digoxin levels in the pencillamine-treated animals were significantly lower, P
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