Abstract
The method of modification of the metrazol seizure by beta-erythroidin hydrochloride used by other investigators is here applied to the treatment of schizophrenic children, in whom the incidence of fractures sustained by unmodified metrazol convulsions appears high. The physiological effect of the drug is discussed in its application to the diminution of strength of muscular contraction, and modification of the convulsion. Modification of the seizures has resulted in preventing fractures in 9 of 1O cases, the tenth patient sustaining a fracture through a delayed, unmodified seizure. It is suggested that by avoidance of the use of prostigmine, the danger of this complication may be decreased. The safety of this method of modification is assured by careful technique of administration. Clinical results show that 8 of 9 schizophrenic children treated (including two previously treated by unmodified shock) have shown improvement in response to metrazol therapy. Final evaluation of the efficacy of metrazol treat...
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