Abstract
Summary Five cases of acute infective laryngotracheobronchitis in infants and two cases of staphylococcus bacteriemia in children, which were treated with a new sulfonamide drug (sulfamethylthiazol), are briefly described. With dosages varying from 1 1/2 grains (0.09 Gm.) to 3 grains (0.19 Gm.) per pound of body weight per twenty-four hours, a satisfactory and effective concentration of the drug in the blood was obtained. The clinical response to the medication in these severe staphylococcus infections was striking. An improvement in the method of determining blood drug values is mentioned. Experiments on absorption and excretion are now in progress. The possibility of the occurrence of peripheral neuritis, which to date, has been observed only in adults, and its bearing upon the use of sulfamethylthiazol are discussed.
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