Abstract
Rabbit or mouse globin mRNA was injected into fertilized eggs of Xenopus laevis. Of the injected eggs, 30% survived to the swimming tadpole stage, and 15% became frogs. Sephadex and carboxymethyl cellulose chromatography was used to show that rabbit or mouse globin was synthesized continuously by embryos and tadpoles up to the stage when feeding commenced (c. 8 days after fertilisation). The rate of protein synthesis rises greatly during development, but the rate of rabbit or mouse globin synthesis in frog embryos remains approximately constant for at least 8 days of development, during which about 20 cycles of cell division take place. For mouse haemoglobin mRNA, the ratio of α to β globin synthesis does not change during this period. We conclude that injected globin mRNAs are stable during development.
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