Abstract
A mathematical model is formulated for describing the transient substrate response in a continuous flow stirred tank reactor containing immobilized enzyme particles. The model considers the effects of internal and external substrate diffusion resistances as well as the inherent enzyme denaturation. Simulation of the model so formulated using the kinetic and physical parameters which are within the practical operating range, reveals that a substrate response minimum occurs in all the cases under consideration. Such a substrate response minumum is significantly affected by several characteristic dimensionless groups which govern the reactor performance equations. The unsteady state simulation is also extended to two CSTRs in series. It is found that the substrate response characteristics in the second reactor are similar to these in the first except for a much lower substrate concentration level.
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