The Transient effects of COX-2 inhibitor on osteogenic differentiation in canine bone marrow-derived mesenchymal stem cells

Abstract

s / Osteoarthritis and Cartilage 21 (2013) S63–S312 S107 differences were found between limbs for the external sagittal and frontal plane moments at the hip joint, subjects demonstrated greater external adduction moment at the knee of the SX side compared to the NSX side (MD: 0.12 0.11 Nm/Kg, p1⁄4.013, d1⁄41.09). Conclusions: The Hip Harris Score, pain level, and abductor strength suggest that the SX hip is more impaired than the NSX limb. Subjects also ambulate with a compensatory lateral trunk lean toward the affected limb, but continue to demonstrate greater adduction angles on the SX limb during single limb stance. These movement abnormalities may represent the primary movement impairments and may be related to the unilateral hip abductor weakness observed in this sample. Unilateral impairments may also contribute to the significantly larger knee adduction moment on the NSX limb. Figure 1. Average trunk lean angle (A) and hip frontal plane angle (B) during the stance phase of gait for the surgical limb (solid black line) and non-surgical limb (dashed red line). Positive angles represent lean toward the stance leg (A) and adduction (B). Black-striped area represents the standard deviation for the surgical limb. Red-squared area represents the standard deviation for the non-surgical limb. 185 THE TRANSIENT EFFECTS OF COX-2 INHIBITOR ON OSTEOGENIC DIFFERENTIATION IN CANINE BONE MARROW-DERIVED MESENCHYMAL STEM CELLS N. Oh, T. Sunaga, S. Kim, K. Hosoya, M. Okumura. Hokkaido Univ.,