Abstract
The invasive potential of cancer cells is mediated in part through the action of matrix metalloproteinases (MMP), which degrade the extra-cellular membrane and promote metastasis. The transcription regulatory region of MMP genes contains binding sites for Ets transcription factors. While the underlying mechanism of MMP regulation is unclear, the Ets transcription factor PEA3 has been shown to be involved. We have previously reported that expression of PEA-3 is associated with the co-activator AIB-1, HER2 positivity, metastasis, and reduced disease free survival.
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