Abstract
During tumorigenesis, the recently identified tumor-specific memory Tcells in draining lymph nodes (TdLN-TTSM cells) play a pivotal role in tumor repression that gives rise to progenitor exhausted T (TPEX) cells and further replenishes tumor-specific CD8+ Tcells residing in the tumor microenvironment (TME). However, how TTSM cells are maintained in TdLN is largely unknown. Here, we show that the transcription regulator ID3 (inhibitor of DNA binding 3) is highly expressed by TTSM cells compared with other CD8+ Tcell subsets. The deficiency of ID3 significantly interrupts the maintenance of TTSM and TPEX cells, resulting in decreased tumor-infiltrating CD8+ Tcells and impaired tumor control. Consistent with this, overexpression of ID3 in CD8+ Tcells increases the TTSM cell population and enhances the anti-tumor immune response.
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