Abstract

Type I invariant NKT cells (iNKT) are a subset of αβ T cells characterized by the expression of an invariant Vα14-Jα18 TCRα chain. iNKT cells derive from CD4+CD8+ double positive thymocytes (DP), and their generation requires a long DP thymocyte half-life, to allow for Vα14-Jα18 rearrangements, expression of glycolipid-loaded CD1d on DP thymocytes, and signaling through the SLAM/SAP pathway. Here we show that c-Myb plays a central role in priming DP thymocytes to enter the iNKT lineage by simultaneously regulating CD1d expression, DP half-life, and expression of SLAMF1, SLAMF6 and SAP.

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