The Traditional Uses, Phytochemistry and Pharmacology of Sarcandra glabra (Thunb.) Nakai, a Chinese Herb With Potential for Development: Review.

Yuanlian Zeng,Qiang Zhang,Junyu Liu,Guojuan Sun,Zulun Li,Shenrui Jin,Xuhua Qin

doi:10.3389/fphar.2021.652926

Yuanlian Zeng, Qiang Zhang + Show 5 more

Open Access

https://doi.org/10.3389/fphar.2021.652926

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Abstract

Sarcandra glabra (Thunb.) Nakai is a folk medicine with a long history in China, which has been applied to treat sore throat, abscess, even tumor and so on. Meanwhile, it is also used as tea in some areas. At present, more than 200 chemical compounds have been isolated and identified from it, such as, sesquiterpenes, flavonoids, phenolic acids, coumarins and so on. Pharmacological studies have already confirmed that the extracts of S. glabra have many effects, such as antibacterial, antiviral, anti-inflammatory, anti-tumor, and anti-thrombocytopenia, especially the effects of anti-tumor and anti-thrombocytopenia are confirmed in clinic. Therefore, this paper systematically summarized the traditional uses, botany, phytochemistry, pharmacology, and toxicity of S. glabra, in order to provide a beneficial reference of its further research.

Highlights

S. glabra is a perennial evergreen plant belonging to the Chloranthaceae family, and its resources are widely distributed throughout China, Japan, Korea, and Southeast Asia (Xu et al, 2011)
What’s more, the ethanol extract of S. glabra could reduce pulmonary edema, inhibit viral replication in lung tissue and alleviate oxidative stress level in mice infected with H1N1 virus, and its mechanism may be related to activating nuclear factor-erythroid 2-related factor 2 (Nrf-2)/heme oxygenase-1 (HO-1) pathway to regulate superoxide dismutase (SOD), malondialdehyde (MDA) and nitric oxide (NO) to reduce oxidative stress injury (Huo et al, 2020)
Because of its significant pharmacological effects, such as antibacterial, antiviral, anti-inflammatory, antitumor and anti-thrombocytopenic effects that are found in modern studies, S. glabra has attracted extensive attention

Summary

Introduction

S. glabra is a perennial evergreen plant belonging to the Chloranthaceae family, and its resources are widely distributed throughout China, Japan, Korea, and Southeast Asia (Xu et al, 2011). Coumarins and flavonoids isolated from the antibacterial fraction of S. glabra showed good antibacterial activity (Wang and Ma, 1979b; Xu et al, 2008; Yuan et al, 2008).

Results

Conclusion