Abstract
A quantitative histochemical investigation has been made of the types of acidic glycoprotein produced by the mucous and serous cells of the bronchial submucosal glands in patients with cystic fibrosis. No qualitative abnormalities could be identified in the types of acidic glycoproteins produced in this disease. There was a decrease in the proportion of mucous cells producing sialomucin and an increase in the proportion producing sulphated mucin, as in the case of the mucous cells of adults with bronchiectasis in the absence of cystic fibrosis. It was concluded that there was no primary abnormality in the acidic mucins produced by bronchial mucous cells in patients with cystic fibrosis and that the change in the proportion of cells producing the different acidic mucins was a secondary phenomenon related to the bronchial damage.
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