Abstract
The protective effects of red cabbage and garlic extracts against liver, kidney and thyroid gland damage induced by fumonisin B1 (FB1) in male mice were studied. Sixty mice divided in to six groups. Group one are the healthy mice, Group two are mice that received a daily oral dose of only FB-1 (100 µg/kg.b.w) for 1 month, Group three: are mice that received red cabbage extract (500 mg/kg.bw) plus FB1, Group four: are mice that received red cabbage extracts, Group five: are mice that received garlic extract (500mg/kg.bw) plus FB1, group 6:are mice that received only garlic extract. After finishing the experiments, samples of blood were used for biochemical examination. The results indicated that group (2) mice treated with fumonisin B1 had significantly increased levels of immunoglobulins (IgG and IgM), kidney function parameters (urea and creatinine), proteins (albumin and total protein (TP)), and thyroid hormones (T3 and T4), along with significantly decreased level of TSH (p < 0.05). In the LD50 experiment, we are choose concentration (100 µg/kg.b.w) gavage to the mice. Oral administration red cabbage garlic extracts produced significantl reduction the levels serum IgG, IgM, T3, T4, urea, creatinine, TP and albumin and with a significant increase in TSH.
Highlights
The mycotoxins have been considered as natural secondary metabolites that have low molecular weight
After oral gavage of fumonisin B1 (FB1) toxin (100 μg/kg) to mice, death occurred at 200 Mg, and no death was observed in male mice using the concentrations of 50 Mg and 100Mg as shown in table (1)
Consumption of FBs has been associated with increased incidence of esophageal cancer The (IARC)
Summary
The mycotoxins have been considered as natural secondary metabolites that have low molecular weight. Epidemiological data, in addition to in vitro researches, propose that cabbage has anti-oxidant phytochemical compounds, with strong protective impacts against the main degenerative diseases, such as cancer [18] and cardiovascular diseases They were reported to have antihyperglycemic [19] and hypocholesterolemic [20] properties. Determination of the median lethal dose of FB1 Laboratory Animals: Thirty-six male Swiss albino mice (1 month-old, 24±2 gram weight), obtained from the Biotechnology Researches Center / Al- Nahrain University, Baghdad, Iraq, were adapted to experimental conditions for two weeks before starting the experiments They were maintained under the laboratory environment of diet, water, and temperature at the animal house in the Center. Determination of serum immunoglobulin G The quantitative determination of mouse IgG was achieved with the use of enzyme-linked immunosorbent assay (ELISA) mouse IgG Kit (Catalog No: 501240) (EIA- Cayman company, USA) Such immunological assay is based on the double-antibody sandwich method. The formation rate of the colored complex is considered to be proportional to creatinine concentrations
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
