The toxic effect of aflatoxin on chromosomal aberration and sperm morphology of albino male mice Mus musculus L

Abstract

Aflatoxins are mycotoxins found as a foodstuff contaminant, but some of them are seen to increase cancer risk. Aflatoxins are the most potent natural toxin recognized. The sperm shape and chromosomal aberration test were used to investigate the effect of aflatoxin on albino male mice. The aim of this research is to assess the cytogenetic and sperm toxic effects of aflatoxin in albino male mice in vivo. The doses used were (control, 10, 20, and 30) mg/kg/bw for 24 hours. Our results reveal that aflatoxin can cause a range of chromosomal malformations like chromatid break without fragment, ring chromosomes, dicentric chromosomes, centromeric break, chromatid gap, and fragment chromosomes the abnormalities increased from 5 in control to 62.2 in 30mg/kg. and sperm abnormalities in male albino mice subjected to various doses were hookless, headless, tailless, defective head, long and broad hook, folded head, folded tail, and sperm with double tail, increasing the dose concentration enhanced the rate of it when compared to untreated mice from17.6 in control to 136.4 in the highest dose.