Abstract

One of the important problems in system biology is to discover the relationship between topological properties and functional features of proteins in protein-protein interaction (PPI) networks. There are many essential-nonhub proteins and lots of nonessential-nonhub proteins in the PPI network. Both essential-nonhub proteins and nonessential-nonhub proteins are low-connectivity proteins, but they have different lethality. In order to explain why nonessential-nonhub proteins are not essential, we compare them with essential-nonhub proteins from topological view. The comparison results show that there are statistical differences between nonessential-nonhub proteins and essential-nonhub proteins in centrality measures and clustering coefficient.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.