Abstract
The sea star Asterias rubens includes TNFR, in its genome, when compared to mouse one: mouse isoform 2 of TNF AIP3-interacting protein 1, mouse TNF receptor-associated factor 2, mouse TNF receptor-associated factor 3, mouse TNF receptor-associated factor 4, mouse TNF receptor-associated factor 6. Many of these factors are bound to NF Kappa -B genes which have recently been isolated in the Asterias rubens genome. They play a role in the regulation of the sea star immune system.
Highlights
Tumor necrosis factor receptor (TNFR)- associated factors belong to a family of intracellular adaptor proteins that mediate signaling downstream of various cell surface receptors, including members of the TNFR superfamily [1]
TNFR have been described in mammals, Drosophila and Caenorhabditis elegans and are characterized by conserved structural motifs [2]
It is true that Liu [2] has identified a Drosophila TNF receptorassociated factor:DTRAF1, but not really the mouse TNF receptorassociated factor 2 which is found in Asterias rubens: we may speak of homologies between these factors
Summary
Tumor necrosis factor receptor (TNFR)- associated factors belong to a family of intracellular adaptor proteins that mediate signaling downstream of various cell surface receptors, including members of the TNFR superfamily [1].TNFR have been described in mammals, Drosophila and Caenorhabditis elegans and are characterized by conserved structural motifs [2].TNFR are related to detective activation of kinases and/or transcription factors such as NF Kappa-B. Tumor necrosis factor receptor (TNFR)- associated factors belong to a family of intracellular adaptor proteins that mediate signaling downstream of various cell surface receptors, including members of the TNFR superfamily [1]. TNFR have been described in mammals, Drosophila and Caenorhabditis elegans and are characterized by conserved structural motifs [2]. TNFR are related to detective activation of kinases and/or transcription factors such as NF Kappa-B. NF Kappa-B genes have been discovered recently in Asterias rubens [3]. We research TNFR, in immunized and nonimmunized sea stars to HRP, in their genome, when compared to mouse genome
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