Abstract
Abstract The tissue distribution of amidopyrine and its metabolites 4-amino-antipyrine and N-acetyl-4-amino-antipyrine has been determined at intervals following oral doses of 300 mg/kg of amidopyrine in pregnant, non-pregnant and foetal rabbits, and also in adult non-pregnant rats. Except in lung, their concentration was higher in the normal rabbit than the rat. In both species amidopyrine levels were maximal at 2 hr, but the metabolite levels varied with tissue, species and time interval. The dominant pathways were demethylation in the rabbit and acetylation in the rat. Plasma and tissue levels of amidopyrine were higher in non-pregnant than pregnant rabbits, whereas those of the metabolites varied. Studies indicate that 25-day, but not 14-day foetuses may metabolize amidopyrine.
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