The tidal breathing lung function in very low birth weight preterm infants with bronchopulmonary dysplasia

Abstract

Objective To investigate the development of tidal breathing lung function in very low birth weight infants with bronchopulmonary dysplasia(BDP). Methods Two hundred and sixty-two very low birth weight infants hospitalized in Wenzhou Children′s Hospital were enrolled as objects.All infants were given the tidal breathing pulmonary function test within a week before discharge and at the corrected age of 6 to 8 months.According to clinical diagnosis, they were divided into BPD group(n=65) and non-BPD group(n=197), and BPD group were divided into mild group(n=31), moderate group(n=20) and severe group(n=14) according to the severity.The lung function indexes were compared between different groups. Results The results of the test within a week before discharge displayed that the respiratory rates in the BPD groups were higher than those in the non-BPD group(all P 0.05). The result at the corrected age of 6 to 8 months displayed that TPEF, TEF75, TEF50, TEF25 in severe BPD group were still higher than those in any other group(all P 0.05). Conclusion Preterm infants BPD have different degrees of lung injury, but as the age grows some lung function indexes can improve gradually(at the corrected age of 6 to 8 months). However, early severe small airway obstruction is still serious.Therefore, it′s important to prevent and treat BPD for the prevention and regulation of respiratory tract disease in future. Key words: Bronchopulmonary dysplasia; Tidal breathing pulmonary function; Very low birth weight infant,