Abstract
The thyroidal radioactive iodine (I131) uptake alone has only been of limited value as a diagnostic aid in the differential diagnosis of nontoxic thyroid disease. However, measurement of the thyroidal uptake of radioactive iodine (I131)* before and after the administration of thyroid-stimulating hormone (thyrotropin) has greatly enhanced the usefulness of this diagnostic tool. The purpose of this paper is to describe the results of the thyroid-stimulating hormone (TSH) test in patients having various nontoxic thyroid diseases with and without goiter and patients with normal thyroid function. Review of the Literature Stanley and Astwood1first demonstrated that in patients with normal thyroid function (euthyroidism) a single injection of TSH caused a significant increase in the rate of thyroidal uptake of I131at the end of 8 hours which reached its peak at the end of 24 hours. They noted that the duration of the increased rate of
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