Abstract
The surface thrombogenicity of atheromas, conventional endarterectomy (CE), laser endarterectomy (LE), and laser angioplasty (LA) were compared in the rabbit arteriosclerosis model. Normal ( N = 6) and arteriosclerotic ( N = 15) rabbits underwent thoracoabdominal exploration. Multiple CEs and LEs were performed in 12 arteriosclerotic rabbits leaving a segment of intact atheroma between each endarterectomy. Multiple LAs were performed in three arteriosclerotic rabbits. Argon ion laser radiation was used for all laser procedures. Blood (0.05 ml) from normal rabbits was placed on the CE surface, LE surface, LA surface, atheroma, and normal intima and clotting times were determined. Surface thrombogenicity was calculated as the ratio of the clotting time of the CE, LE, LA, or atheroma to normal intima. Surface thrombogenicity was 1.0 ± 0.03 for normal intima (control), 0.58 ± 0.06 for atheromas ( P < 0.001), 0.46 ± 0.08 for CE ( P < 0.001 from atheromas), 0.46 ± 0.08 for LE ( P = NS from CE), and 0.27 ± 0.09 for LA ( P < 0.001 from CE and LE). The thrombogenicity of LE is the same as the thrombogenicity of CE. Both forms of endarterectomy are less thrombogenic than LA in the rabbit model.
Highlights
Powered by the California Digital Library University of CaliforniaBERNS, PH.D. The surface thrombogenicity of atheromas, conventional endarterectomy (CE), laser endarterectomy (LE), and laser angioplasty (LA) were compared in the rabbit arteriosclerosis model
Multiple conventional endarterectomy (CE) and laser endarterectomy (LE) were performed in 12 arteriosclerotic rabbits leaving a segment of intact atheroma between each endarterectomy
Blood (0.05 ml) from normal rabbits was placed on the CE surface, LE surface, laser angioplasty (LA) surface, atheroma, and normal intima and clotting times were determined
Summary
BERNS, PH.D. The surface thrombogenicity of atheromas, conventional endarterectomy (CE), laser endarterectomy (LE), and laser angioplasty (LA) were compared in the rabbit arteriosclerosis model. Multiple CEs and LEs were performed in 12 arteriosclerotic rabbits leaving a segment of intact atheroma between each endarterectomy. 0 1987 Academic press, Inc. Argon ion laser radiation of arteriosclerotic plaques has been shown to leave carbonized debris and thermal disruption of several cell layers beneath the luminal surface [ 1, 5, 9, 12, 131. We have attempted to minimize thermal injury to the arterial surface by performing open laser endarterectomy rather than closed laser angioplasty with the argon ion laser [4,5,6,7]. This report evaluates the surface thrombogenicity [ 19,231 of argon ion laser endarterectomy in an experimental rabbit arteriosclerosis model
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