The third variant of human myoglobin showing an unusual amino acid substitution: 138 (H16) arginine → tryptophan

Abstract

A new human myoglobin variant is described which appears to have an Arg → Trp mutation at position 138 (H16). It is the first example of an Arg → Trp substitution, none so far having been found in many families of proteins. Assuming that this substitution arises from a single point mutation, it defines the RNA codon for the 138th residue of human myoglobin as CGG and that for another variant 138 Arg → Gln as CAG.