Abstract
Purpose: This study was performed to determine whether one drop of topical administration of Coqun® (Coenzyme Q10 and Vitamin E)-a potent antioxidant-twice a day has any effect on the thiol-disulphide homeostasis-a novel oxidative stress marker in the Retinopathy Of Prematurity (ROP) disease course. Methods: This was a prospective observational study comprising 28 infants with ROP at stage 2 and higher who followed up at the paediatric intensive care unit. Ferric reducing power of plasma (FRAP), albumin, ischemia-modified albumin (IMA) and thiol disulphide homeostasis levels were studied in the infants before and two weeks after Coqun® treatment. Results: The mean gestational age was 27 (24–32) weeks, the mean birth weight was 1,012±326 g and the mean duration of care in an incubator was 64±23 days. FRAP levels were 0.91±0.17 μmol/L, IMAs were 0.85±0.29, native thiols were 248±38.9 μmol/L and total thiols were 284±39.2 μmol/L, respectively, at the beginning of therapy. FRAP levels 0.79±0.21(p= 0.006) μmol/L, IMAs 0.73±0.36(p = 0.096), native thiols 262±42.6(p = 0.164) μmol/L and total thiols 291±43.6(p = 0.344) μmol/L showed no difference after two weeks of therapy. Conclusion: Thiol disulphide homeostasis levels do not change with Coqun® therapy during ROP course.
Highlights
Retinopathy Of Prematurity (ROP) is a proliferative vasculopathy that usually develops in infants with low birth weight and low gestational age because of vascular dysfunction of the retina
This study was performed to determine whether one drop of topical administration of Coqun®, a potent antioxidant consisting of Coenzyme Q10 (CoQ10) 0.1% (w/v) and vitamin E TPGS (d-alphatocopheryl polyethylene glycol 1000 succinate) 0.5% (w/v) dissolved in aqueous saline isotonic solution [16], twice a day has any effect on the thiol-disulphide homeostasis in the ROP disease course
Twenty-eight premature infants with a mean gestational age of 27.6 ± 1.99 (24–32) weeks, a mean birth weight of 1012 ± 318 (520–1750) g and a mean duration of care in the incubator of 64 ± 28 (15–120) days were included in the study
Summary
Retinopathy Of Prematurity (ROP) is a proliferative vasculopathy that usually develops in infants with low birth weight and low gestational age because of vascular dysfunction of the retina. The most significant factors are oxidative stress caused by oxygen (O2). Oxidative stress represents the imbalance between the production of Reactive Oxygen Species (ROS) and protective antioxidants [5]. Because oxygen in the retina is supplied from the choroid, hyperoxygenation is observed in the inner and outer retina due to the lack of autoregulation between the choroid and the retina as well as inadequate antioxidant defence mechanism, in premature infants. Hyperoxygenation causes oxidative stress in the retina, which plays an important role in ROP development [6 - 8]. Expression of Vascular Endothelial Growth Factor (VEGF), which causes neovascularisation in the retina, is regulated by signals associated with hypoxia [9]. Oxidative stress plays a role in pathological processes, including the regulation of VEGF expression in the retina [10]
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