Abstract
The thiocyanate suppression test, as described in the present paper, has proved to be a useful diagnostic assay in patients in whom the thyroidal radioiodine uptake or the clinical findings are equivocal. Thiocyanate, administered during 2 days by mouth at a total dose of 3 g, caused a sharp decrease in the 24-hr I131 uptake in 9 euthyroid patients and in 28 subjects with nontoxic diffuse goiter or nontoxic nodular goiter. No value exceeded 20%. In contrast, no value under 20% was obtained in 17 patients with thyrotoxicosis following thiocyanate administration.
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